Marco Carotenuto graduated from Università degli Studi della Campania Luigi Vanvitelli. He is Senior Researcher from 2011 to November 2017in Child and Adolescent Neuropsychiatry at the Università degli Studi della Campania Luigi Vanvitell. In December 2017 he was appointed as the Associate Professor of Child and Adolescent Neuropsychiatry at the Università degli Studi della Campania Luigi Vanvitell. He was awarded with Best scientific contribution oral presentations from X Congress Italian Society of Orthopedics And Medicine, Florence, Best Oral Communication Award from Napule é Congress and he is one of the Honorary member of the New Medical School Salernitana. He had published totally 114 articles in reputed journals.

Epilepsy, Idiopathic generalized epilepsy, Childhood absence epilepsy, EEG, Sleep, Memory and Learning, Electroencephalography, Neurological Diseases, Clinical Neurology, Neuroimaging, Neurophysiology.

Marco Carotenuto graduated from Università degli Studi della Campania Luigi Vanvitelli. He is Senior Researcher from 2011 to November 2017in Child and Adolescent Neuropsychiatry at the Università degli Studi della Campania Luigi Vanvitell. In December 2017 he was appointed as the Associate Professor of Child and Adolescent Neuropsychiatry at the Università degli Studi della Campania Luigi Vanvitell. He was awarded with Best scientific contribution oral presentations from X Congress Italian Society of Orthopedics And Medicine, Florence, Best Oral Communication Award from Napule é Congress and he is one of the Honorary member of the New Medical School Salernitana. He had published totally 114 articles in reputed journals.

Epilepsy, Idiopathic generalized epilepsy, Childhood absence epilepsy, EEG, Sleep, Memory and Learning, Electroencephalography, Neurological Diseases, Clinical Neurology, Neuroimaging, Neurophysiology.

Dr. Denis Larrivee is a Visiting Scholar at the Mind and Brain Institute, University of Navarra Medical School and Loyola University Chicago and has held professorships at the Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University's Medical School he received the Association for Research in Vision and Ophthalmology's first place award for studies on photoreceptor degenerative and developmental mechanisms. He is the editor of a recently released text on Brain Computer Interfacing with InTech Publishing and an editorial board member of the journals Annals of Neurology and Neurological Sciences (USA) and EC Neurology (UK). An International Neuroethics Society Expert he is the author of more than 80 papers and book chapters in such varied journals/venues as Neurology and Neurological Sciences (USA), Journal of Neuroscience, Journal of Religion and Mental Health, and IEEE Explore. In 2018 he was a finalist in the international Joseph Ratzinger Expanded Reason award.

Neurobiology, Neuroscience, Neurology, Psychiatry, Ophthalmology, Cognitive Neuroscience, Neuroimaging, Cognitive Neuropsychology, Ethics.

Long-Jun Wu completed his PhD in neurobiology from University of Science and Technology of China in 2004. He was trained as postdoctoral fellow at University of Toronto and Harvard Medical School (2004-2010). Dr. Wu was appointed as an Instructor at Harvard Medical School (2011-2012) and an Assistant Professor at Rutgers University (2012-2016). Since 2016, Dr. Wu is an Associate Professor in Department of Neurology at Mayo Clinic. His research interests mainly focus on neuroimmune interactions in normal and diseased brain. He has published more than 95 peer-review research papers, including those in Nature Neuroscience, Nature Communicaitons, Science Translational Medicine, Neuron, PNAS, Cell Reports etc..,

Neuroimmune interactions in normal and diseased brain, Neuroscience and Neurobiology.

Dagmar Amtmann is a psychologist and UW research associate professor with the Department of Rehabilitation Medicine. Dr. Amtmann's research interests include improving measures of patient reported outcomes such as pain, fatigue, and participation using modern measurement theories; statistical analytic approaches using multilevel and latent variable modelling; and instructional, information, and assistive technology for individuals with cognitive disabilities (with a particular focus on reading and writing technology for both children and adults).

Improving measures of patient reported outcomes such as pain, fatigue, and participation using modern measurement theories; statistical analytic approaches using multilevel and latent variable modelling; and instructional, information, and assistive technology for individuals with cognitive disabilities.

Raffaele Pilla, Pharm.D., Ph.D., Doctor Europaeus, received his Master’s degree in Pharmacy at G. d’Annunzio University in Chieti-Pescara, Italy in 2005, where he also served internships at the Cell Physiology Laboratory and Molecular Biology Laboratory. Prior, he was an Erasmus Student at Faculté de Pharmacie de Reims in Reims, France. He received his Doctor Europaeus in 2010 from Pitié-Salpétrière Institute in Paris, France. Also in 2010, he received his Ph.D. in Biochemistry, Physiology, and Pathology of Muscle at G. d’Annunzio University in Chieti-Pescara, Italy. He was hired as a Postdoctoral Scholar in the Department of Pharmacology and Physiology at the University of South Florida in Tampa, on two research grants funded by the Office of Naval Research (US Navy) and Divers’ Alert Network. He has written and lectured widely worldwide. He has been involved in on-going research at the University of South Florida with the use of ketone esters.

Epileptic seizures and Brain cancer, Ketogenic diets, Oxygen toxicity, Physiology, Ketone Esters adopted in the metabolic treatment of epilepsy and cancer, Ketogenic Diet administered in patients affected by epilepsy and cancer.

• Dr Attarian is currently a professor of neurology and medical director of sleep medicine and sleep fellowship at Northwestern University. He graduated with a MD in 1992 from American University of Beirut and completed residency in Neurology at Upstate Medical University in Syracuse and fellowships in epilepsy and sleep medicine at University of Rochester and Hennepin County Medical Center respectively. He has Published 70 peer reviewed papers, 20 chapters and three textbooks. He has lectured nationally and internationally including Shanghai China and Moscow Russia and participated in 30 research projects and got three grants. He has won teaching awards.

Hrayr Attarian primary research interests are in sleep disorders in women and the treatment of parasomnias,Epilepsy.

Joseph I. Sirven, M.D., is a professor of neurology and editor-in-chief of Epilepsy.com. He is currently chair of the AAN Education Meeting Subcommittee and he is on the board of directors for the American Brain Foundation and the editorial board of Neurology Now. Previously, he served as director of education for Mayo Clinic's Arizona campus with oversight over all educational activities at the Arizona campus, including medical student rotations, residencies, fellowships, Ph.D. candidates, nursing, allied health and continuing medical education programs. He was the previous chair of Neurology at Mayo Clinic's campus is Arizona and the previous vice chair of the Epilepsy Section of the American Academy of Neurology, chair of the Communication Council for the American Epilepsy Society and former chair of the Professional Advisory Board for the Epilepsy Foundation.

Epilepsy and seizure treatments in adults and children (particularly older adults) Epilepsy surgery Electroencephalography Investigational anti-epilepsy drugs Status epilepticus Vagal nerve stimulator Ketogenic diet

Dr. Alain L. Fymat is a medical-physical scientist and an educator who was educated at the Universities of Bordeaux and Paris-Sorbonne, France, and the University of California at Los Angeles. He is the current President/CEO and Professor at the International Institute of Medicine & Science. He was formerly Professor of Radiology, Radiological Sciences, Radiation Medicine (Oncology), Critical Care Medicine, and Physics at several U.S. and European Universities. His current research interests lie at the interface between science and medicine (neurological disorders; precision medicine; nanobiotechnology; nanomedicine; genetics/epigenetics/ecogenetics; and drug delivery across the brain protective barriers). He has extensively published (~350 scholarly publications) and lectured in several national and international academic, professional, governmental and industrial venues. He is a a Board member of several institutions, and Editor-in-Chief, Honorable Editor or Editor of twelve scientific Journals.

Radiology, Medicine

Antonio Gambardella is full professor of Neurology in the Department of Medical and Surgical Sciences, University Magna Graecia - Catanzaro, Italy. He is a clinical neurologist and clinical researcher with a special interest in establishing close research links with basic scientists. His group, together with molecular genetic collaborators in Italy, discovered in 2000 the beta2 nicotinic acetylcholine receptor gene for nocturnal frontal lobe epilepsy and subsequently has been involved in the discovery of other epilepsy genes. A more recent important scientific result has been the discovery of novel gene KCNT1 associated with a severe form of progressive myoclonus epilepsy. He has also focused on clinical and neurophysiological aspects, and genetics of temporal lobe epilepsy, the most common type of focal epilepsy. He is currently an active investigator of the "Epi25" Collaborative group that has developed from an initiative coming out of the NIH National Human Genome Research Institute (NHGRI) and the International League Against Epilepsy (ILAE) Consortium on Genetics of Complex Epilepsies to make more rapid progress towards fully understanding the inherited components of epilepsies

Epilepsy, Neurology

Natalia Rodríguez Álvarez is the Postdoctoral research Scientist in the department of Physiology and Medical Physics in the Epilepsy Research Group at the Royal College of Surgeons in Ireland. Combining the principles of molecular biology and neurobiology, electroencephalography, pharmacology and genetics at both undergraduate and postgraduate level has led to a broad knowledge base in a multidisciplinary field with additional experience in drug discovery and biomarkers.

Epilepsy,Medicine

Dr. K. S. Ravi holds M.D. Anatomy degree from India’s most prestigious Institute, JIPMER Pondicherry.He has worked as an Assistant Professor in Sri Venkateshwara Medical College Hospital & Research Centre in Pondicherry & Sri Muthukumaran Medical College Hospital & Research Institute, Chennai. Before Joining AIIMS Rishikesh on 18th August 2012 as faculty of Anatomy, Dr. Ravi was working as Assistant Professor and Course Director & Head of Anatomy at School of Medicine, Spartan Health Sciences University, St. Lucia, North America. Dr.Ravi has been Assistant Dean(Academics) and presently working as Sub-Dean(Academics),AIIMS Rishikesh.Apart from his contributions to the field of medicine, Dr. Ravi is also a creative writer. He was awarded the “Best Creative Writer” in 1997 for one of his stories. His articles have been published in various magazines and leading national newspapers of India, including- The Times of India, The Pioneer and The Hindustan times. He has furthered his literary interests by serving on the editorial boards and reviewers of several National – International Journals and magazines

Neuroanatomy,Medicine,Health Sciences

Dr.Ameen Al-KAMALI is professor of Neurosurgery at Ain Shams University. Faculty of medicine at Sana'a University

Neurology, Neurosurgery,Child and Adolescent Neurology

Roberto Alexandre Dezena M.D. is from Federal University of Triângulo Mineiro, Uberaba, Brazil (2003), medical residency in Neurosurgery at Santa Casa de Misericórdia de Ribeirão Preto, Brazil (2009), Ph.D. in Neurosurgery at Ribeirão Preto Medical School of University of São Paulo, Brazil (2011), and Postdoctoral Fellowship at Federal University of Triângulo Mineiro, Uberaba, Brazil (2014). Fellow of Eberhard-Karls Universität Tübingen, Germany, Hiroshima University, Japan, and Saint Louis University, USA. In Brazil, he is Full Member of Brazilian Society of Neurosurgery (SBN) and Brazilian Academy of Neurosurgery (ABNc), besides vice president of Minas Gerais Neurosurgery Society and member of deliberative counsil of Brazilian Academy of Neurosurgery. Internationally, he is Fellow of World Federation of Neurosurgical Societes (WFNS), Active Member of International Federation of Neuroendoscopy (IFNE), Active Member of International Society for Pediatric Neurosurgery (ISPN), Active Member of Walter E. Dandy Neurosurgical Society (WEDNS), and Full Member of both Latin American Federation of Neurosurgery Societes (FLANC) and Latin American Group of Studies in Neuroendoscopy (GLEN). Currently is Associate Professor and Chief of Division of Neurosurgery, Clinics Hospital, Director of Neurosurgery Residency Program and Professor of Postgraduate Program in Health Sciences and Postgraduate Program in Applied Biosciences, all at Federal University of Triângulo Mineiro, Uberaba, Brazil. Director of the Reference Center for Continuing Education of Latin American Federation of Neurosurgery Societes (FLANC), at the same university. Neurosurgical activities in Microneurosurgery (vascular and neuro-oncology), Endoscopic Neurosurgery, Pediatric Neurosurgery, Spine Surgery and Neurotrauma. Furthermore is editorial board member and reviewer of several international scientific journals, highlighting World Neurosurgery (WFNS), Neurological Research (Maney) and Journal of Neurosurgical Sciences (Minerva).

Neurology,Neurosurgery , Pediatric Neurosurgery, Endoscopic Neurosurgery,Neurotrauma, Spine Surgery

Riaz Ahmed Competent and well trained neurologist with 2 European certifications and Fellowship: Fellow of Royal College of Paediatrics and Child Health, UK as well Fellow of Royal College of Physicians of Ireland - Comfortable with all aspects of neurology, including Epilepsy management In Paediatrics and neurophysiology (electroencephalography and electromyography). Has more than 40 publications in Peer viewed Neurology Journals - Editorial board member in 3 International Neurology Journals. - Member of International Child Neurology Association, Asian Oceanean Child Neurology Association, Indian Neurological Society, Infantile |Seizure Society & American Academy of Neurology.He is currently working as Consultant & Head of Paediatric Neurology at KFAFH

Epilepsy management In Paediatrics and neurophysiology (electroencephalography and electromyography).

Dr. Dan Suiaga With a rich experience in all types of neurosurgical interventions, Dr. Dan Suiaga is recognized for interventions in complex spinal surgery (implants and spinal reconstruction, etc.), but also for cerebral vascular surgery or skull base. Although he started his professional training at the neurosurgery department of the University Hospital in Cluj-Napoca, Dr. Dan Suiaga continued to train outside the borders of Romania, in countries such as Switzerland, Israel, Germany and South Africa.

Clinical Science

Dr. Francisco Javier Ruiz Miyares is a Neurologist with a varied range of interests within clinical neurology, mainly epilepsy of childhood onset. Diverse aspects from teaching to research within a clinical praxis framework, encompass his goals including semiology-semiothecnia, neurophysiology, epidemiology with an exchange platform as a congress organizer, being the former Neurology Conferences, now NeuroSantiago events, a successful pathway of interaction amongst many neuroscientists from diverse part of the world. Master of Sciences in Infectology, Assistant Professor and Second Degree Specialist and Researcher, was CME coordinator of the World Federation of Neurology in the eastern part of the island more than 10 years

Neurology,Epilepsy,Neuroscience,Pediatric Neurology,Neurophysiology and Epidemiology

Intractable seizures plague approximately a third of epilepsy patients. Despite their prevalence, the mechanisms underlying intractable seizures remain unclear and difficult to study. One factor clouding our understanding of seizure intractability stems from existing animal models of epilepsy, which have not specifically modeled intractable seizures or genetic disorders that often associate with intractable seizures, like Focal Cortical Dysplasia (FCD) or Tuberous Sclerosis Complex (TSC). New animal models are greatly needed to understand the underlying causes of intractable seizures and develop new therapies aimed at these indications. Using in utero electroporation to transfect a small population of neurons in vivo with constitutively active mutant of Ras homolog enriched in brain (RhebCA), we have successfully developed a new mouse model of spontaneous epilepsy based on the genetic etiology of mTOR-o-pathies. This model recapitulates both anatomical and behavioral phenotypes of human TSC and FCD. RhebCA transfected animals develop focal cortical malformations that contain dysplastic neurons, cortical dyslamination and white matter heterotopia. Seizures also spontaneously develop as early as postnatal day18, and persist throughout entire lifespan of the animals (2 years). Seizures are the only complication these animals have, otherwise they are completely healthy, making them ideal subjects to study mechanistic causes of seizures and seizure-dependent downstream behavioral and physiological effects. With this model, we have elucidated several mechanisms that contribute to seizure-genesis in TSC and FCD. Lastly, we also use this model to develop new therapies, including novel cannabinoids and RNA interference approaches to mitigate refractory seizures

Neuroscience , Neurosurgery

Dr.Omar García is currently a Professor from university Anáhuac with the Department of Neurology.He is the Neurosurgeon at Mexican Society of Neurological Surgery. Dr.Omar done his education from National Autonomous University of Mexico. He is also invited Professor at Pre and postgraduate courses. He is the member of Neuro trauma section

Neurosurgery,Tumors, Skull base, Derivation systems,Vascular surgery,CNS infections Spine surgery,Congenital disease,Degenerative disease,Tumors Fixation and instrumentation Trauma

Annamaria Vezzani obtained her PhD degree in Neuropharmacology in Milano at the Mario Negri Institure for Pharmacological Research. She spent her post-doctoral period at the Univeristy of Maryland in Baltimore working on the mechanisms of seizures generation in experimental models of epilepsy. Additional post-doctoral periods were done at the Univeristy of Stockholm and at the Karolinska Institute. She was on sabbatical at the Albert Einstein College of Medicine in 2002 in the laboratory of Developmental Epilepsy. She studies the biochemical and molecular mechanisms involved in the pathogenesis of seizures and epileptogenesis using experimental models. The present research is focused on the role of neuroactive inflammatory mediators in aberrant neuronal excitability underlying seizures. Focus of research is also on the mechanisms of pharmacoresistance. She has published over 160 original papers, several book chapters and reviewes in peer-reviewed high impact scientific journals (h-index 62). Since 1997 she is Head of the Laboratory of Experimental Neurology in the Department of Neuroscience at the Mario Negri Institute for Pharmacological Research, Milan, Italy. She is member of the Editorial Board variuos scientific journals includingf Epilepsy Res, Epilepsy and Treatments and Neuroscience, and she has been for 8 years Associate Editor of Basic Science for Epilepsia. She has been appointed of the Chair of the Commission on Neurobiology of International League Against Epilepsy (2005-2009) which is promoting initiatives for improving translational research in epilepsy. She is now liason member of the Commission on Neurobiology and active member of the CEA of the ILAE and various AES committees. She received the Research Recognition Award for translational research in 2009 by the American Epilepsy Society.

Neuropharmacology,Experimental Neurology,Translational Research in Epilepsy

Dr. Sanjoy Sanyal is Associate Dean, Clinical Neuroscience Professor, Surgeon and Informatician in Texila American University, Guyana, South America. He holds double Master's degrees from India and UK. He has published more than 50 papers in print and online journals. He is a Neuroscience editor and peer-reviewer of WebmedCentral. He has posted more than 300 Neuroscience videos online, accompanied by his running commentaries. He is currently writing a Neuroscience book for medical students. He has presented papers in more than 10 international forums. He holds a provisional patent from USPTO on a computerized program for staging 26 human cancers.

Neuroscience

Dr.Jera KRUJA is a Member of Scientific Committee at European Academy of Neurology and Professor of Neurology at Mother Theresa University Hospital Center. Since 2014 she is (European representative) at Teaching Course Committee, World Federation of Neurology. During 2013-2014 she is a Rector of University of Medicine, Tirana and Member of editing board of OA Publishing London, WebMed Central Brain Editor, Albanian Medical Journal, Bulletin of Medical Sciences, University of Medicine, Tirana. She worked at Health National Contact Point, European Commission, CORDIS Fp7 programme(2010-2013). From 2003, she is a reviewer of European Journal of Neurology, Clinical Epidemiology, Neuropsychiatric Disease and Treatment, Journal of Epidemiology and Community Health, Journal of Pediatric Epilepsy. She is a Trainer of European Academy of Epilepsy since February 2003. She is the President of Albanian Society of Neurology (ASN) during 1998-2007.

Neurology, Neuroradiology, Epidemiology

Dr. Alberto E. Musto, M.D., Ph.D., F.A.E.S., is an Assistant Professor of Pathology and Anatomy, one of the Module Directors of the CareForward Curriculum, School of Medicine and Director of the Neuroanatomy, School of Health Professionals at Eastern Virginia Medical School in Norfolk, Virginia. Dr. Musto integrates an interdisciplinary approach in medical education and mentorship activities in neuroscience research in order to enhance research and diversity in the new medical curricula. Dr. Musto’s scientific goal is to identify potential biomarkers and preventive therapies for epilepsy. He has been bestowed with a lifetime professional honor in recognition of his accomplishments and dedication to excellence in epilepsy by the American Epilepsy Society. He has published in major journals in the field of neuroscience and epilepsy and he has been a member of NIH grant review study sections. Prior to join EVMS, Dr. Musto was at Louisiana State University Health Science Center, New Orleans, where he completed his postdoctoral fellowship in neuroprotection and worked as an Assistant Professor of research in Neuroscience and Neurosurgery. Prior to that, Dr. Musto started his career in Buenos Aires, Argentina where he received board certifications in both neurology and radiology, completed postgraduate studies in medical education, management in health systems and a doctoral thesis in neurobiology. Dr. Musto has been involved in academic medicine during his entire career and is a regular speaker at national and international conferences.

Neurobiology and Neuroanatomy

Dr. Hallowell served more than eight years as Associate Dean for Research and Sponsored Programs in Ohio University’s College of Health and Human Services and six years as Director of the School of Hearing, Speech and Language Sciences. Given her extensive experience in boosting successful publication and extramural funding successes of students and faculty members, she is frequently invited to provide action-focused workshops on research career development and on ways to foster productive interdisciplinary and international collaboration in research and education.

Neurogenic Language Disorders, Global Health, Technology Transfer, Engaged Teeaching/Learning Methods

Jane Paulsen is a Chair in Neuroscience from Roy J. Carver, and Professor of Psychiatry, Neurology, Psychology. Her education is BS, Psychology with honours, Simpson College, Indianola, and completed IAMS, Psychology, from Columbia University, New York, NY. She did PhD in Counselling Psychology (APA accredited) from University of Iowa. She got Post Doctorate in Neuropsychology specialization in Alzheimer's disease from University of California, San Diego, and CA. Her Research Summary includes neural basis of cognition; preclinical deficits in dementia gene-carriers; frontal subcortical deficits, particularly Huntington's disease Research in this laboratory uses tools of neuropsychology and cognitive psychology to examine behavioral correlates of brain dysfunction. Topics of current interest include subtypes of Alzheimer's disease, preclinical cognitive deficits associated with gene-carriers of Huntington's disease and clinical/imaging correlates of cognitive measures. Functional MR and PET are used to examine frontal-striatal circuitry dysfunction in these disorders.

Alzheimer's disease, Huntington's disease , Parkinson's disease, Epilepsy.

Mr Mbusomuni Mahlalela (the national director) is the founder and of the Swaziland Epilepsy Organization. The organization was founded in 2002 and registered in 2004. The mandate for the organization is to raise awareness and to help reduce stigmatization associated with people living with epilepsy in the country. In 2006 the SEO affiliated with the IBE. The national director was a vise chairperson in the Road Safety Awareness Council(Epilepsy and Driving). Meetings that have been attended by the national director includes inter alia; Epilepsy Congress in Rome, Dubai 2 times ,Kenya and South Africa.The SEO has worked closely in sharing ideas with the South African Epilepsy Organization which has ensured the introduction of the South African Epilepsy golf in Mpumalanga branch. In Swaziland the national director has ensured the initial start up of the following; 1.epilepsy and driving campaign 2. Swaziland golf day (annual event) 3.Epilepsy yellow valentines 4.Epilepsy marathon 5.Epilepsy happy mother's day 6.Epilepsy cycling 7.Epilepsy support groups initiatives to help sustain the livelihoods for people living with epilepsy. 8. Mbusomuni Mahlalela has worked closely with the Swaziland government and parliament to ensure the availability of epilepsy equipment, and drugs furthermore the rights of people living with epilepsy . and the our website can let what I did for the country about epilepsy.

epilepsy

Educational Background and Academic Titles 1968 M.D., Tokyo University Faculty of Medicine 1968 Residency at Tokyo University Hospital 1969 Residency at Tokyo Police Hospital 1973 Research Fellow at Sainte Anne Hospital(Professeur J Talairach), 1973-1975 1976 D.M.Sc.,Board of Japan Neurological Surgery 1981 Associate Professor, Department of Neurosurgery, Tottori University 1984 Professor, Department of Neurosurgery, Tottori University 1995 Director, Institute of Neurological Sciences, Tottori University 1998 Chairman and Professor, Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University 2009 Emeritus Professor of Tokyo Women’s Medical University Honoured President of Moriyama Memorial Hospital(Tokyo) 2012 Honoured President of Moriyama Memorial Hospital(Tokyo) Honoured President of Shin Yurigaoka Genreral Hospital(Kanagawa) 2016 President of Tokyo Neurological Center Hospital Board ECFMG 1968 Japanese Neurosurgical Society (No 699) Japanese Epilepsy Society (No 33) Japanese Rehabilitation Society (Clinical Board 3718) Japanese Cerebral Stroke Society (No20030046) Japanese Neuroendoscope society (No1) Endoscopy for pituitary adenomas, craniopharyngiomas, and acoustic tumors. Japanese Headache Society, Japanese Dementia Society

Neurosurgery , Epilepsy

My background consists of hippocampal anatomy at light and electron-microscopic levels, in non-human primates and rodents. During PhD my work was focused on experimental models of temporal lobe in rodents. During this time I gained experience in anatomical studies, specially aiming to identify seizure-induced damage in the entire brain and in hippocampal plastic changes caused or related to seizures. My first postdoctoral experience was in the anatomy department under supervision of Ole Peter Ottersen, when I gained abilities to use the electron microscopy as tool to identify the sublocalization of glutamate receptors in the hippocampus. Back to Brazil, now under supervision of Luiz Mello, we focused on the establishment of a new model of temporal lobe epilepsy in non-human primates. I conducted studies examining behavioral and electrophysiological recordings of seizures as well as histological analysis. At the same time I started to use the magnetic resonance imaging as tool to investigate morphological changes in several brain areas after status epilepticus and in chronic epilepsy. In 2006 I got a permanent position as professor at Universidade Federal of Sao Paulo. Since them, I have followed two research lines: (1) experimental models of temporal lobe epilepsy and (2) experimental models of neonatal pain. In both lines I have focused my research on neuroplastic changes caused by these models and its consequences on electrophysiological and behavioral levels. By using Manganese-enhanced MRI, we have been able to demonstrate that hippocampal remodeling after seizures can be followed in both research models. From my research on epilepsy, I was able to demonstrate that thalamic Deep Brain Stimulation (DBS) is a valuable tool to reduce cell apoptosis and inflammatory responses after pilocarpine-induced status epilepticus. By conducting DBS experiments in the chronic phase of pilocarpine, my students and I were able to demonstrate that it causes reduction of spontaneous seizures, reduces the hippocampal excitability and increases adenosine in the same area. The mechanisms underlying the adenosine actions in response to thalamus DBS are still under investigation. I am presently engaged in a number of collaborative efforts between my laboratory and various other laboratories focusing to understand how DBS affects neural networks. These studies include behavioral evaluation, record EEG and ex-vivo electrophysiology and MRI. These collaborations allow me to draw from a broad array of scientific expertise. In summary, my combined research experience in surgical implantation of electrodes, DBS, behavioral neuroscience and MRI will afford me an essential expertise and experience that will facilitate the successful implementation of the experiments outlined in this application.

Epilepsy

Leon D. Iasemidis was born in Athens, Greece, and received the Diploma degree in Electrical and Electronics Engineering from the National Technical University of Athens, Athens, Greece. He subsequently earned the M.S. degree in Biomedical Engineering, the M.S. degree in Physics and the Ph.D. degree in Biomedical Engineering from the University of Michigan, Ann Arbor, MI, USA. He was a Postdoctoral Fellow at the University of Michigan (1991–1993), a Research Assistant Professor of electrical and computer engineering, neurology, and neuroscience at the University of Florida, Gainesville, FL, USA, the Director of the clinical neurophysiology laboratory, neurology service, Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL (1993–1997), and a tenured Associate Professor in biomedical engineering at the Arizona State University, Tempe, AZ, USA. Since 2012, he has been the Rhodes Eminent Scholar Chair and Professor of biomedical engineering at the Louisiana Tech University, Ruston, LA, USA, the Founder and Director of the Brain Dynamics Laboratory (http://www.braindynamics.latech.edu), the Director of the multidisciplinary Center for Biomedical Engineering and Rehabilitation Science (http://coes.latech.edu/cbers) at Louisiana Tech University, and a Professor Emeritus of the Arizona State University. He held an adjunct professorship in neurology (2009–2012) at Mayo Clinic Arizona, and currently holds adjunct professorships in neurology (2013) at the Louisiana State University Health Sciences Center, Shreveport, LA, and neurosurgery (2015) at the University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA. His research interests include the areas of biomedical signal processing, complex systems theory and nonlinear dynamics, neurophysiology, monitoring and analysis of the electrical and magnetic activity of the brain in epilepsy and other brain dynamical disorders, intervention and control of CNS. His research has been highlighted in multiple forums, including the New York Times, Discover magazine, the Teaching Company, and the American Society for the Advancement of Science. He is internationally recognized as an expert in nonlinear dynamics, the detection, prediction and control of crises in complex coupled systems, is one of the founders of the field of seizure prediction and of two companies in this area. His research and more than 100 peer-reviewed publications, patents, interdisciplinary conference organizations, presentations, and invited talks have stimulated an international interest in the prediction and control of epileptic seizures and understanding of the mechanisms of epileptogenesis. His research has been funded by National Institute of Health, VA, Defense Advanced Research Projects Agency, National Science Foundation, DoD, the Whitaker Foundation, the Epilepsy Foundation of America, CURE, the Science Foundation of Arizona, and medical device industry. Prof. Iasemidis is a Fellow of the American Institute of Medical and Biological Engineers (AIMBE) and a Fellow of the National Academy of Inventors (NAI). He has served on the editorial board of Epilepsia, the IEEE Transactions on Biomedical Engineering and the International Journal of Neural Systems, and currently is an Associate Editor of the Annals of Biomedical Engineering and a member of the editorial board of the journal of Epilepsy Research. He is a reviewer for the National Institutes of Health, the National Science Foundation, and several other national and international funding agencies and foundations.

Brain Dynamics in Epilepsy

Domenico Ursino received the MSc Degree in Computer Engineering from the University of Calabria in July 1995. He received the PhD in System Engineering and Computer Science from the University of Calabria in January 2000. From November 2000 to December 2004, he was an Assistant Professor at the University Mediterranea of Reggio Calabria. From January 2005, he is an Associate Professor at the University Mediterranea of Reggio Calabria. From November 2015, he is a Vice Rector, Responsible for Information Technology, of his University. He is author of more than 160 papers. His research interests include Neurological Network Analysis, Social Internetworking, Social Network Analysis, Knowledge Extraction and Representation, Source and Data Integration, Multi-Agent Systems, Recommender Systems.

Neurological Network Analysis, Social Internetworking, Social Network Analysis, Knowledge Extraction and Representation, Source and Data Integration, Multi-Agent Systems, Recommender Systems.